Why is amlodipine contraindicated in pregnancy?

Animal studies have shown significantly decreased litter size, increased intrauterine deaths and prolongation of gestation and duration of labor when this drug was given before mating, throughout mating, and during gestation. There are no controlled data in human pregnancy.

Why is amlodipine not given in pregnancy?

Amlodipine falls into category C. There are no good studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if amlodipine will harm your unborn baby.

Is amlodipine safe to use during pregnancy?

Mito and colleagues concluded that, based on this admittedly small sample, amlodipine exposure in early pregnancy does not appear to be associated with an increased rate of fetal malformations compared with other antihypertensive medications or maternal hypertension without treatment.

Can amlodipine cause birth defects?

Conclusion: As reported with other calcium-channel blockers, amlodipine does not appear to be teratogenic and it appears to be compatible with breastfeeding.

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Why are calcium channel blockers contraindicated in pregnancy?

Calcium channel blocker use in the third trimester was associated with increased risk of neonatal seizures, jaundice, and hematologic disorders (relative risk [RR] 3.6, 95% CI 1.3 to 10.4).

What BP medication is safe in pregnancy?

Table 1

Guideline Measuring BP in pregnancy
ACOG [17] Rest for 10 minutes or longer
Abstain from tobacco or caffeine use for 30 minutes before measurement (III)
Take BP in upright position
For patients in hospital BP can be taken sitting up or in left lateral recumbent position, patient’s arm at level of heart (III)

Is telmisartan safe in pregnancy?

Telmisartan is an antihypertensive medication, which acts as an angiotensin II receptor antagonist, and has an inhibitory effect on the renin-angiotensin system. Telmisartan is contraindicated in pregnancy; adverse effects have been reported in both animal and human pregnancies (2).

Which calcium channel blockers are safe in pregnancy?

Is it safe to use a calcium channel blocker other than nifedipine in pregnancy? Nifedipine is the CCB for which the most information has been collected and is therefore commonly used in pregnancy.

Is chlorthalidone safe during pregnancy?

Taking chlorthalidone during pregnancy may cause side effects in the newborn baby, such as jaundice (yellowing of the skin or eyes), bruising or bleeding, low blood sugar, or an electrolyte imbalance. Do not start or stop taking chlorthalidone during pregnancy without your doctor’s advice.

Why is nifedipine contraindicated in angina?

Relative Contraindication

[13] In severe aortic stenosis, nifedipine can cause ventricular collapse and dysfunction. In unstable angina, nifedipine causes a reflexive increase in cardiac contractility, which increases myocardial oxygen demand and worsens the ischemia.

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Why is hydralazine given during pregnancy?

For many years, hydralazine has been the recommended antihypertensive of first choice for severe hypertension in pregnancy. Its side effects (such as headache, nausea, and vomiting) are common and mimic symptoms of deteriorating pre-eclampsia.

Why is terbutaline used in pregnancy?

Terbutaline is a medication used to delay preterm labor. It is in a class of drugs called betamimetics, which help prevent and slow contractions of the uterus.

What are the contraindications of amlodipine?

Amlodipine is contraindicated in patients with known hypersensitivity to amlodipine or its dosage form components. In addition, amlodipine is relatively contraindicated in patients with cardiogenic shock, severe aortic stenosis, unstable angina, severe hypotension, heart failure, and hepatic impairment.

When are calcium channel blockers contraindicated?

Calcium channel antagonists are also contraindicated in patients with known hypersensitivity to the drug or its components. Other contraindications include sick sinus syndrome (except in patients with an artificial pacemaker), severe hypotension, acute myocardial infarction, and pulmonary congestion.

Which antihypertensive drugs are contraindicated in pregnancy?

Both labetalol and methyldopa are considered safe for use in pregnant women,12,13 while angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARB) are contraindicated during all trimesters of pregnancy based on their potential teratogenic and fetotoxic effects,1 though this is …